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Clinical studies of Nembutal have not included sufficient numbers of subjects aged 65 and over to determine whether elderly subjects respond differently from younger subjects. Other reported clinical experience has not identified differences Con responses between the elderly and younger patients.
Capable of producing all levels of CNS depression—from mild sedation to hypnosis to deep coma to death.
Dosages of barbiturates must be individualized with full knowledge of their particular characteristics and recommended rate of administration.
Hepatic impairment: As clinical patronato regarding the use of pentobarbital in hepatic impairment are lacking, pentobarbital should be used with caution.
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: For all uses of pentobarbital: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
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Possible withdrawal symptoms Per neonates born to women who received barbiturates throughout the last trimester of pregnancy. Premature neonates are particularly susceptible to the depressant effects of barbiturates.
The sodium salt occurs as a white, slightly bitter powder which is freely soluble Durante water and alcohol but practically insoluble in benzene and ether.
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Barbiturates are pregnancy category D drugs and have been shown to cause fetal damage if used Per pregnant patients. This class of drugs can traversone the placental barrier and distribute throughout the fetal tissue with the highest concentrations Per get more info mezzo di the liver, brain, and placenta.
The concomitant use of alcohol or other CNS depressants may produce additive CNS depressant effects.
CNS effects appear to be related, at least partially, to the drug's ability to enhance activity of GABA, the principal inhibitory neurotransmitter in pentobarbital for sale the CNS, by altering inhibitory synaptic transmissions that are mediated by GABAA receptors.